Constructions d'anticorps multivalentes

Multivalent antibody constructs

Abstract

The invention relates to a multivalent Fv antibody construct comprising at least four variable domains which are connected to one another via peptide linkers 1, 2 and 3. The invention also relates to expression plasmids which code for such an Fv antibody construct. In addition, the invention relates to a method for producing the Fv antibody constructs and to the use thereof.

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Cited By (11)

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    US-8337841-B2December 25, 2012Chugai Seiyaku Kabushiki KaishaMethods of screening for antibody light chains
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    US-9241994-B2January 26, 2016Chugai Seiyaku Kabushiki KaishaPharmaceutical compositions containing sc(Fv)2
    US-9334331-B2May 10, 2016Chugai Seiyaku Kabushiki KaishaBispecific antibodies
    US-9670269-B2June 06, 2017Chugai Seiyaku Kabushiki KaishaMethods of modifying antibodies for purification of bispecific antibodies
    US-9777066-B2October 03, 2017Chugai Seiyaku Kabushiki KaishaPharmaceutical compositions containing sc(Fv)2