Method for regulating heteroplasmy of mitochondrial dna



【課題】 ミトコンドリア病や老化に伴い、大きな欠失変異を持つmtDNAが正常なmtDNAよりも優先的に複製する現象であるミトコンドリアの不均一化を制御する方法を提供すること。 【解決手段】 NTG1遺伝子又はその産物を用いて、ミトコンドリアDNAの不均一化を制 御する方法。 【選択図】 なし
<P>PROBLEM TO BE SOLVED: To provide a method for regulating heteroplasmy of mitochondria which is a phenomenon preferentially reproducing mtDNA having a large deletion mutation than the normal mtDNA, accompanied by mitochondrial disorders or aging. <P>SOLUTION: The method regulates heteroplasmy of mitochondrial DNA by using a NTG1 gene or its product. The method preferably expresses the NTD1 gene product in a cell by transducing an expression vector including the NTG1 gene into the cell. <P>COPYRIGHT: (C)2006,JPO&NCIPI




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Patent Citations (2)

    Publication numberPublication dateAssigneeTitle
    JP-2003024097-AJanuary 28, 2003Inst Of Physical & Chemical Res, 理化学研究所System for detecting mutant group affecting establishment of mitochondoria dna homoplasmy
    JP-2005087150-AApril 07, 2005Institute Of Physical & Chemical Research, 独立行政法人理化学研究所ミトコンドリアdnaの遺伝的均一化促進方法

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